Caspase-3 Inhibitor I

Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Product does not compete with ATP.

Target IC₅₀: 200 pM against caspase-3

Primary TargetCapase-3, capase-6, capase-7, capase-8, capase-10

General description

A specific and reversible inhibitor of CPP32/Apopain/Yama (IC₅₀ = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.

A very potent, specific, and reversible inhibitor of caspase-3 (IC₅₀ = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.Nicholson, D.W. 1996. Nature Biotech. 14, 297.Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.Nicholson, D.W., et al. 1995. Nature376, 37.

Packaging

1 mg in Glass bottle

5 mg in Plastic ampoule

Yes

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

Ac-Asp-Glu-Val-Asp-CHO

Warning

Toxicity: Standard Handling (A)